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KMID : 0385219920020020133
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Korean Journal of Gerontology
1992 Volume.2 No. 2 p.133 ~ p.141
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Age-Dependencies of Crosslinking of Type I Collagen from Rat Skeletal Muscle
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Yang Ryung
Shin Wan-Chul
Eum Sung-Yong
Shin Dong-Bum
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Abstract
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Type I collagen was purified from rat dorsi muscle. The changes in collagen cross-links and the content of pyridinoline during aging were determined. The electrophoretic analysis showed that type I collagen from aged animal muscle contained more high molecular polymer. Extractability in acid and neutral solvent and digestion rate by collagenase decreased with the progress of aging. The amount of pyridinoline, cross-linker of collagen fibrils increased during maturation and then decreased.
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KEYWORD
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collagen, crosslink, aging, pyridinoline
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